New CF Research Could Improve Treatments For Muscle Function

The research paper, Skeletal Muscle Oxidative Capacity in Patients with Cystic Fibrosis, published in Experimental Physiology in March 2015, has concluded that people suffering from Cystic Fibrosis have a lesser ability to uptake and use oxygen in their muscles, which leads to exercise intolerance.

This genetic disease affects the organs in people with Cystic Fibrosis (CF), primarily the lungs and digestive system, which become obstructed by excessive and thick mucus which makes breathing and digesting food difficult.

This research study found that those with CF have shown a limited ability to uptake and use oxygen in their muscles which then also gets more pronounced with age. This lack of oxygen can lead to a limited ability to exercise, and exercise is considered important for achieving a better quality of life, and prolonged life.

The researchers of this study used NIRS (Near Infrared Spectroscopy) as a method to evaluate skeletal muscle oxidative capacity in a group of patients with Cystic Fibrosis. They compared skeletal muscle oxidative capacity within a group of 13 patient aged 7-42 years with CF, and a control group of 16 healthy people aged 7-59 years. The NIRS device was placed on the middle of the thigh and a cuff, much like a blood pressure cuff, was placed on the upper thigh. The pressure cuff was then inflated on the thigh to measure muscle tissue oxygen response over time.

Read Skeletal Muscle Oxidative Capacity in Patients with Cystic Fibrosis >

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